This project combines plant biology, breeding, genetics, and bioinformatics and engages key industry partners in order to (1) reveal the underlying mechanisms of beneficial metabolite production in sorghum grain using ‘omics’-based approaches and computational biology and (2) apply this information to optimize sorghum hybrids for food and feed end-uses with the assistance of genomics-enabled breeding.  This proposal leverages a unique public-private partnership to expand the understanding of secondary metabolites in sorghum and to utilize this applied research to develop a series of nutritionally optimized hybrids for human health and animal feed (pet and livestock).